PMC Lab
Research
Peptidomimetics:
Peptidomimetics are designed to mimic the biological activity of peptides while overcoming their limitations, such as poor stability, low bioavailability, and rapid degradation in the body. These synthetic analogs are prepared with an aim to retain the beneficial properties of peptides, including high specificity and potency, while enhancing their therapeutic potential. It is achieved by modifying the peptide backbone/side chain, introducing non-peptide elements, or employing constrained structures to mimic the active conformation of peptides. This approach helps in creating more stable and metabolically resistant molecules, making them promising candidates for drug development.
At PMC Lab, we are focused on the design, synthesis, and characterization of novel peptidomimetics to explore their potential in various therapeutic applications. Our research aims to address the challenges faced by conventional peptide-based drugs and contribute to the advancement of peptidomimetic science for improved clinical outcomes.
The effect of various synthesized Connecting peptide (C-peptide) mimics in our lab on Glucose Utilization and GLUT4 translocation. Also, a possible pathway depicting glucose metabolism by C-peptide mimics.
Self-Assembly of Hybrid Peptides:
Nature constructs complex functional systems through the spontaneous association of molecules into structured aggregates via molecular self-assembly, demonstrating advanced capabilities in recognition, selection, and target specificity. The design and precise construction of self-assembling systems presents a challenging yet rewarding endeavor, aiming to understand and replicate various biological systems that employ multiple non-covalent interactions, such as hydrogen bonding and Van der Waals forces etc., to perform diverse processes, including protein folding and molecular recognition.
Drawing inspiration from nature, our laboratory is focused on utilizing these non-covalent forces to create a variety of Hybrid peptide-based bio-mimetic systems capable of forming unique morphologies via controlled self-assembly that are potentially capable of performing various biological functions including recognition of diverse targets.
Diverse range of morphologies achieved through the controlled self-assembly of hybrid peptides
Heterogeneous Peptide Catalysts:
Heterogeneous peptide catalysis offers a greener and more innovative alternative to traditional catalysis due to the inherent benefits of using catalysts, a key principle of green chemistry. These reactions typically utilize oxygen-stable reagents and do not require anhydrous conditions, which helps lower synthesis costs. Moreover, peptide-catalyzed reactions occur under mild conditions, making them compatible with various functional groups that might be sensitive in other processes. This compatibility reduces the need for protective groups, thereby decreasing the overall number of reaction steps. Additionally, this approach employs less toxic and safer substances, prevents the formation of metallic waste, and avoids metal traces in the final products—an essential aspect of medicinal chemistry applications.
We are currently engaged in the development of hybrid peptide-based reusable catalysts capable of driving various important transformations required for the synthesis of fine chemicals and APIs in the laboratory as well as on a pilot scale.